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IMAGE: In this image of a neuron nucleus, bright spots show areas of focused genetic repair. view more
Credit: Salk Institute/Waitt Advanced Biophotonics Center
LA JOLLA (April 1, 2021) Neurons lack the ability to replicate their DNA, so they re constantly working to repair damage to their genome. Now, a new study by Salk scientists finds that these repairs are not random, but instead focus on protecting certain genetic hot spots that appear to play a critical role in neural identity and function.
The findings, published in the April 2, 2021, issue of
Science, give novel insights into the genetic structures involved in aging and neurodegeneration, and could point to the development of potential new therapies for diseases such Alzheimer s, Parkinson s and other age-related dementia disorders.
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New DNA-based technique allows researchers to determine age of living beluga whales in Alaska
Researchers can now determine the age and sex of living beluga whales in Alaska’s Cook Inlet thanks to a new DNA-based technique that uses information from small samples of skin tissue.
Accurate age estimates are vital to conservation efforts for Cook Inlet belugas, which were listed as endangered following a significant population decline in the 1990s. Previously, researchers could only determine the age of beluga whales by studying the teeth of dead animals.
The new aging method uses DNA methylation data and machine learning to develop a model that captures the relationship between methylation and age. This relationship provides an epigenetic clock for beluga whales.
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IMAGE: A gray beluga whale calf with three adults in Cook Inlet, Alaska. NMFS ESA/MMPA Permit #20465. view more
Credit: Paul Wade, NOAA Alaska Fisheries Science Center.
NEWPORT, Ore. - Researchers can now determine the age and sex of living beluga whales in Alaska s Cook Inlet thanks to a new DNA-based technique that uses information from small samples of skin tissue.
Accurate age estimates are vital to conservation efforts for Cook Inlet belugas, which were listed as endangered following a significant population decline in the 1990s. Previously, researchers could only determine the age of beluga whales by studying the teeth of dead animals.
Cook Inlet beluga whales. Photo credit: NOAA Fisheries
NEWPORT, Ore. – Researchers can now determine the age and sex of living beluga whales in Alaska’s Cook Inlet thanks to a new DNA-based technique that uses information from small samples of skin tissue.
Accurate age estimates are vital to conservation efforts for Cook Inlet belugas, which were listed as endangered following a significant population decline in the 1990s. Previously, researchers could only determine the age of beluga whales by studying the teeth of dead animals.
The new aging method uses DNA methylation data and machine learning to develop a model that captures the relationship between methylation and age. This relationship provides an epigenetic clock for beluga whales.