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IMAGE: In this image of a neuron nucleus, bright spots show areas of focused genetic repair. view more
Credit: Salk Institute/Waitt Advanced Biophotonics Center
LA JOLLA (April 1, 2021) Neurons lack the ability to replicate their DNA, so they re constantly working to repair damage to their genome. Now, a new study by Salk scientists finds that these repairs are not random, but instead focus on protecting certain genetic hot spots that appear to play a critical role in neural identity and function.
The findings, published in the April 2, 2021, issue of
Science, give novel insights into the genetic structures involved in aging and neurodegeneration, and could point to the development of potential new therapies for diseases such Alzheimer s, Parkinson s and other age-related dementia disorders.