Could saffron be an effective supplement for helping manage COVID-19? A new study has explored the potential use of saffron ( Crocus sativus L.) as a supplement for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19). With the increase of mutations in SARS-CoV-2, as well as the mass demand for effective, affordable and safe vaccines rising with each challenge attached to this virus, the exploration of additional medicinal and therapeutic options has been encouraged. Significance of saffron Saffron has been historically used to treat many ailments such as fever, bronchitis, the common cold, as well as other immune respiratory disorders. Saffron is also thought to alleviate symptoms of anxiety, depression, sleep disturbances and post-traumatic stress disorder. These abnormalities are associated with COVID-19, with 30-40% of patients believed to be affected by them. Due to its anti-depressive attributes, saffron may potentially assist those who are experiencing these symptoms, boosting their immunity as well as managing their mental wellbeing.