Mass spectrometry: An important tool to unravel mechanisms underlying Huntington s disease
Mass spectrometry has emerged as an important analytical tool for gaining a better understanding of mechanisms underlying Huntington s disease (HD), alongside the increased availability of cell and animal models of the disease.
This review, published in the
Journal of Huntington s Disease, brings together and recaps data from major published mass spectrometry studies undertaken in HD research over the last 20 years, identifying important changes that occur in HD. The authors encourage researchers to make greater use of these studies to accelerate the development of new treatments.
HD is a rare neurodegenerative disorder caused by the aberrant expression of mutant Huntingtin (HTT) protein containing an expanded polyglutamine tract. Mass spectrometry is a technique that has existed for over a century to measure the mass-to-charge ratio of ions, however, proteins in complex mixtures such as t
Mass Spectrometry a Key Tool in Understanding Huntingdon s Disease
technologynetworks.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from technologynetworks.com Daily Mail and Mail on Sunday newspapers.
Taming the Huntington s disease proteome: Mass spectrometry may provide answers
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.
E-Mail
BOSTON - During the development and progression of Alzheimer s disease, a protein called tau accumulates and spreads in the brain. Understanding the mechanisms behind tau spread and its consequences may point to new prevention and treatment strategies for Alzheimer s disease and other forms of dementia. New insights now come from research that was led by investigators at Massachusetts General Hospital (MGH) and involves an anesthetic known to affect cognitive function. The findings are published in
The scientists note that inflammation plays an important role in Alzheimer s disease, and microglia immune cells that reside in the brain are thought to be involved in this process by producing an inflammatory molecule called interleukin-6. To see if tau stimulates microglia to drive the development of Alzheimer s disease pathology, the MGH investigators and their colleagues conducted experiments with an inhaled anesthetic called sevoflurane. Their previous work showed that sev
E-Mail
BOSTON - During the development and progression of Alzheimer s disease, a protein called tau accumulates and spreads in the brain. Understanding the mechanisms behind tau spread and its consequences may point to new prevention and treatment strategies for Alzheimer s disease and other forms of dementia. New insights now come from research that was led by investigators at Massachusetts General Hospital (MGH) and involves an anesthetic known to affect cognitive function. The findings are published in
The scientists note that inflammation plays an important role in Alzheimer s disease, and microglia immune cells that reside in the brain are thought to be involved in this process by producing an inflammatory molecule called interleukin-6. To see if tau stimulates microglia to drive the development of Alzheimer s disease pathology, the MGH investigators and their colleagues conducted experiments with an inhaled anesthetic called sevoflurane. Their previous work showed that sev