Mass spectrometry: An important tool to unravel mechanisms underlying Huntington s disease
Mass spectrometry has emerged as an important analytical tool for gaining a better understanding of mechanisms underlying Huntington s disease (HD), alongside the increased availability of cell and animal models of the disease.
This review, published in the
Journal of Huntington s Disease, brings together and recaps data from major published mass spectrometry studies undertaken in HD research over the last 20 years, identifying important changes that occur in HD. The authors encourage researchers to make greater use of these studies to accelerate the development of new treatments.
HD is a rare neurodegenerative disorder caused by the aberrant expression of mutant Huntingtin (HTT) protein containing an expanded polyglutamine tract. Mass spectrometry is a technique that has existed for over a century to measure the mass-to-charge ratio of ions, however, proteins in complex mixtures such as t
Mass Spectrometry a Key Tool in Understanding Huntingdon s Disease
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Taming the Huntington s disease proteome: Mass spectrometry may provide answers
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