Do our brains age faster than the rest of our bodies?
April 21, 2021USC
If you feel your brain power diminishing as you advance into middle age and beyond, blame your neural stem cells. In a new study published in
Cell Stem Cell, a team led by USC Stem Cell scientist Michael Bonaguidi demonstrates that neural stem cells the stem cells of the nervous system age rapidly.
“There is chronological aging, and there is biological aging, and they are not the same thing,” said Bonaguidi, an Assistant Professor of Stem Cell Biology and Regenerative Medicine, Gerontology and Biomedical Engineering at the Keck School of Medicine of USC. “We’re interested in the biological aging of neural stem cells, which are particularly vulnerable to the ravages of time. This has implications for the normal cognitive decline that most of us experience as we grow older, as well as for dementia, Alzheimer’s disease, epilepsy and brain injury.”
United-states
Cambridge
Cambridgeshire
United-kingdom
Los-angeles
California
American
Daniel-aaron
Heechul-jun
Galen-resler
Mi-hyeon-jang
Elbert-pu
Credit: Albina Ibrayeva/Bonaguidi Lab
In a new study published in
Cell Stem Cell, a team led by USC Stem Cell scientist Michael Bonaguidi, PhD, demonstrates that neural stem cells - the stem cells of the nervous system - age rapidly. There is chronological aging, and there is biological aging, and they are not the same thing, said Bonaguidi, an Assistant Professor of Stem Cell Biology and Regenerative Medicine, Gerontology and Biomedical Engineering at the Keck School of Medicine of USC. We re interested in the biological aging of neural stem cells, which are particularly vulnerable to the ravages of time. This has implications for the normal cognitive decline that most of us experience as we grow older, as well as for dementia, Alzheimer s disease, epilepsy and brain injury.
United-states
Cambridge
Cambridgeshire
United-kingdom
Los-angeles
California
American
Daniel-aaron
Heechul-jun
Galen-resler
Mi-hyeon-jang
Elbert-pu
E-Mail
IMAGE: From left, Andy McMahon, Lisa Rutledge, Helena Bugacov and Alex Guo hold an impromptu lab meeting. view more
Credit: Christina Gandolfo
Kidney development is a balancing act between the self-renewal of stem and progenitor cells to maintain and expand their numbers, and the differentiation of these cells into more specialized cell types. In a new study in the journal
eLife from Andy McMahon s laboratory in the Department of Stem Cell Biology and Regenerative Medicine at the Keck School of Medicine of USC, former graduate student Alex Quiyu Guo and a team of scientists demonstrate the importance of a molecule called β-catenin in striking this balance.
New-york
United-states
California
San-diego
Albert-kim
Alex-quiyu-guo
Bing-ren
Helena-bugacov
Aaron-brown
Leif-oxburgh
Andrew-ransick
Mandy-mcmahon
Study could lead to the development of novel treatments for drug-resistant cancers
ETC-159, a made-in-Singapore anti-cancer drug that is currently in early phase clinical trials for use in a subset of colorectal and gynecological cancers, could also prevent some tumors from resisting therapies by blocking a key DNA repair mechanism, researchers from Duke-NUS Medical School and the Agency for Science, Technology and Research (A STAR) in Singapore reported in the journal
EMBO Molecular Medicine.
Among the many therapies used to treat cancers, inhibitors of the enzyme poly (ADP ribose) polymerase (PARP) prevent cancer cells from repairing naturally occurring DNA damage, including unwanted/harmful breaks in the DNA. When too many breaks accumulate, the cell dies.
Singapore
Ann-lee
David-virshup
Emily-henderson
Agency-for-science
Experimental-drug-development-centre
Assistant-professor-babita-madan
Stem-cell-biology
Professor-david-virshup
Cancer
Cell
Colorectal
vimarsana © 2020. All Rights Reserved.