The Cancer-Compromised Genome
The Graduate College is pleased to present the Teams Live Event: The Cancer-Compromised Genome, a lecture by University Scholar Gary S. Stein, Ph.D. on Monday, March 22, 2021 at 4:30 pm. The event can be joined at http://go.uvm.edu/universityscholars.
A mechanistic and clinical challenge is understanding and treating cancer as a disease of compromised cellular and molecular organization. Cancer onset and progression are functionally associated with aberrant genetic (DNA-encoded) and epigenetic (non DNA-encoded) mechanisms that influence the transmission and retention of regulatory information during cell division. Cancer cells must sustain their compromised genome structure (deletions, amplifications, rearrangements), epigenetic status and function otherwise cancer would be cured by cell division. Each regulatory component of gene expression is linked to architectural organization of regulatory machinery in the cell nucleus. Fidelity of nuclear s
New research from Duke-NUS Medical School, and the Agency for Science, Technology and Research identifies chemotherapy-resistant cancers escape mechanism, which offers new anti-cancer treatment options.
Double trouble for drug-resistant cancers asiaresearchnews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from asiaresearchnews.com Daily Mail and Mail on Sunday newspapers.
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A City of Hope-led research team found that the same gene that increases the risk for Alzheimer s disease, ApoE4, can increase the susceptibility to and severity of COVID-19. Our study provides a causal link between the Alzheimer s disease risk factor ApoE4 and COVID-19 and explains why some (e.g., ApoE4 carriers) but not all COVID-19 patients exhibit neurological manifestations said Yanhong Shi, Ph.D., director of the Division of Stem Cell Biology at City of Hope and co-corresponding author of the new study. Understanding how risk factors for neurodegenerative diseases impact COVID-19 susceptibility and severity will help us to better cope with COVID-19 and its potential long-term effects in different patient populations.