Over the years, everyone loses a few brain cells. A study led by scientists from USC Stem Cell and the USC Neurorestoration Center presents evidence that adults can replenish at least some of what they’ve lost by generating new brain cells, and that
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Do our brains age faster than the rest of our bodies?
April 21, 2021USC
If you feel your brain power diminishing as you advance into middle age and beyond, blame your neural stem cells. In a new study published in
Cell Stem Cell, a team led by USC Stem Cell scientist Michael Bonaguidi demonstrates that neural stem cells the stem cells of the nervous system age rapidly.
“There is chronological aging, and there is biological aging, and they are not the same thing,” said Bonaguidi, an Assistant Professor of Stem Cell Biology and Regenerative Medicine, Gerontology and Biomedical Engineering at the Keck School of Medicine of USC. “We’re interested in the biological aging of neural stem cells, which are particularly vulnerable to the ravages of time. This has implications for the normal cognitive decline that most of us experience as we grow older, as well as for dementia, Alzheimer’s disease, epilepsy and brain injury.”
Neural Stem Cells Decline During Aging
April 14, 2021
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Age-related disorders can be the result of stem cell dysfunction. Identifying the mechanisms that compromise stem cell behavior could be harnessed as targets to restore function. New research elucidates factors that disrupt neural stem cell (NSC) the stem cells of the nervous system function in the hippocampus. It also demonstrated that those NSCs are vulnerable to cellular aging.
This work is published in
“There is chronological aging, and there is biological aging, and they are not the same thing,” said Michael Bonaguidi, PhD, an assistant professor of stem cell biology and regenerative medicine, gerontology, and biomedical engineering at the Keck School of Medicine of USC. “We’re interested in the biological aging of neural stem cells, which are particularly vulnerable to the ravages of time. This has implications for the normal cognitive decline that most of us experience as we grow older, as well as for d