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Molecular Switch Identified That Flips from Self-Renewal to Specialization in the Making of a Kidney
April 5, 2021
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Self-renewal and specialization are two opposing functions in progenitor cells. Scientists resolve the mechanisms behind the opposing developmental actions of beta-catenin, a co-activator of the established molecular Wnt signaling pathway, that paradoxically regulates both self-renewal and specialization of mammalian progenitor cells destined to become kidney cells.
The new study led by Andrew McMohan, PhD, chair of the department of stem cell biology and regenerative medicine at the Keck School of Medicine of University of Southern California, reports high levels of beta-catenin trigger a switch in part of the Wnt pathway that relies on transcription factors known as TCF/LEF.
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IMAGE: From left, Andy McMahon, Lisa Rutledge, Helena Bugacov and Alex Guo hold an impromptu lab meeting. view more
Credit: Christina Gandolfo
Kidney development is a balancing act between the self-renewal of stem and progenitor cells to maintain and expand their numbers, and the differentiation of these cells into more specialized cell types. In a new study in the journal
eLife from Andy McMahon s laboratory in the Department of Stem Cell Biology and Regenerative Medicine at the Keck School of Medicine of USC, former graduate student Alex Quiyu Guo and a team of scientists demonstrate the importance of a molecule called β-catenin in striking this balance.