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Bone-Marrow-Derived Macrophages Promising for Preventing OA – The Horse

ADVERTISEMENT Osteoarthritis (OA) commonly affects horses, yet available therapies have only limited effect on clinical signs and disease progression. In fact, some even block healing mechanisms. Bone-marrow-derived macrophages, a type of white blood cell that produce the anti-inflammatory mediator interleukin-10 (IL-10), however, show promise as a novel OA treatment approach, said Bruno Menarim, DVM, PhD, during his presentation at the 2020 American Association of Equine Practitioners’ Convention, held virtually. Menarim, currently at the University of Kentucky’s Gluck Equine Research Center, in Lexington, reminded his audience that inflammation of the joint’s inner lining, or synovitis, is a hallmark of OA. In the face of acute inflammation, macrophages residing in the joint proliferate and recruit more macrophages from marrow of the long bones nearby to respond to injury. Among other activities, these macrophages (especially the bone marrow macrophages) produce IL-10, reso

Gastric Ulcers: Omeprazole More Effective in Fasted Horses – The Horse

Foal Neurologic Exams: Steps and Signs of Disease – The Horse

ADVERTISEMENT Regardless of whether your mare delivers a seemingly healthy foal or something is not quite right, it’s critical you have your veterinarian conduct a post-foaling exam of the neonate. This examination should include a neurologic assessment. When conducting a neurologic exam on a foal, veterinarians look for subtle and obvious signs of abnormalities that can point to disease in various parts of the nervous system. Monica Aleman, MVZ, PhD, Dipl. ACVIM (LAIM and Neurology), professor of equine internal medicine and neurology at the University of California, Davis, reviewed the key parts of this exam during a presentation at the 2020 American Association of Equine Practitioners’ Convention, held virtually.

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