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Bone-Marrow-Derived Macrophages Promising for Preventing OA – The Horse

ADVERTISEMENT Osteoarthritis (OA) commonly affects horses, yet available therapies have only limited effect on clinical signs and disease progression. In fact, some even block healing mechanisms. Bone-marrow-derived macrophages, a type of white blood cell that produce the anti-inflammatory mediator interleukin-10 (IL-10), however, show promise as a novel OA treatment approach, said Bruno Menarim, DVM, PhD, during his presentation at the 2020 American Association of Equine Practitioners’ Convention, held virtually. Menarim, currently at the University of Kentucky’s Gluck Equine Research Center, in Lexington, reminded his audience that inflammation of the joint’s inner lining, or synovitis, is a hallmark of OA. In the face of acute inflammation, macrophages residing in the joint proliferate and recruit more macrophages from marrow of the long bones nearby to respond to injury. Among other activities, these macrophages (especially the bone marrow macrophages) produce IL-10, reso

Gastric Ulcers: Omeprazole More Effective in Fasted Horses – The Horse

How Veterinarians Can Safely Restrain Down Horses – The Horse

ADVERTISEMENT When a horse is recumbent (down and unable to get up) in a tight spot, one of the first individuals an emotional owner calls is the veterinarian. It’s important that vets and technicians know how to safely and effectively restrain these horses, so they can be extracted and helped back to their feet without injuring themselves or the people around them. However, most veterinarians only gain experience restraining recumbent horses when they’re faced with one. Rebecca Husted, PhD, president of Technical Large Animal Emergency Rescue Inc., described safe restraint practices during a presentation at the 2020 American Association of Equine Practitioner’s Convention, held virtually.

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