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Grayson-Jockey Club Funds Over $2 Million for Research

Grayson-Jockey Club Funds Over $2 Million for Research
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The Oft-Maligned Macrophage, And What It Could Do For Equine Osteoarthritis - Horse Racing News

Turns out, macrophages may be key to healing; could their power be harnessed to treat equine osteoarthritis some day?

Bone-Marrow-Derived Macrophages Promising for Preventing OA – The Horse

ADVERTISEMENT Osteoarthritis (OA) commonly affects horses, yet available therapies have only limited effect on clinical signs and disease progression. In fact, some even block healing mechanisms. Bone-marrow-derived macrophages, a type of white blood cell that produce the anti-inflammatory mediator interleukin-10 (IL-10), however, show promise as a novel OA treatment approach, said Bruno Menarim, DVM, PhD, during his presentation at the 2020 American Association of Equine Practitioners’ Convention, held virtually. Menarim, currently at the University of Kentucky’s Gluck Equine Research Center, in Lexington, reminded his audience that inflammation of the joint’s inner lining, or synovitis, is a hallmark of OA. In the face of acute inflammation, macrophages residing in the joint proliferate and recruit more macrophages from marrow of the long bones nearby to respond to injury. Among other activities, these macrophages (especially the bone marrow macrophages) produce IL-10, reso

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