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Aarhus University The DNA sequences produced are also called oligonucleotides. These are widely used for disease identification, for the manufacture of oligonucleotide-based drugs, and for several other medical and biotechnological applications. The high demand for oligonucleotides therefore requires an efficient automated method for their chemical production.This process relies on phosphoramidites, which are chemical compounds that have the disadvantage of being unstable unless stored at the ideal -20 degrees Celsius. Instruments used for DNA synthesis are not able to cool down the phosphoramidites, and consequently it is unavoidable that some of them degrade after being added to the instrument. Avoiding unwanted degradation of important ingredients

Alexander sandahlKurt gothelfTroels skrydstrupNature communicationsLundbeck foundationResearch fund denmarkDanish national research foundationNovo nordisk foundationProfessor troels skrydstrupIndependent research fund denmarkஇயற்கை தகவல்தொடர்புகள்ஆராய்ச்சி நிதி டென்மார்க்டேனிஷ் தேசிய ஆராய்ச்சி அடித்தளம்சுயாதீனமான ஆராய்ச்சி நிதி டென்மார்க்