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Eureka Advances New Chemical Method for Targeted RNA Medicine
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New chemical method advances toward targeted RNA medicine
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New chemical method advances toward targeted RNA medicine
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Oligonucleotides, or sequences produced by DNA, are the stars when it comes to all the sci-fi things manufactured DNA can do. It is the process that makes them which can go sideways. This process needs phosphoramidites, which tend to be unstable, for setting off the necessary reactions that create oligonucleotides. Temperatures over -4 degrees Fahrenheit threaten their stability. Unfortunately, there is no way to cool them down with the instruments used in DNA synthesis. This can mean they degrade before they are ever put to use.
Chemists Kurt Gothelf, Troels Skrydstrup and Alexander Sandahl, who co-led a study recently published in