Latest Breaking News On - Wyss founding director - Page 2 : comparemela.com

Human Lung Chip Leveraged to Faithfully Model Radiation-induced Lung Injury

Human life-like in vitro model of radiation damage sustained to the lung opens an unprecedented window into the early disease process, and opportunities for drug development

United statesQueeny dasguptaDonald ingberDrug administrationNetwork model for causalityWyss instituteHarvard johna paulson school of engineeringHarvard medical schoolNature communicationsBiologically inspired engineeringHarvard universityBoston childrenWyss founding directorLung alveolus chipLung chipOrgan chip

Human Lung Chip leveraged to faithfully model

Researchers have developed a human in vitro model that closely mimics the complexities of radiation-induced lung injury (RILI) and radiation dose sensitivity of the human lung. Using a previously developed microfluidic human Lung Alveolus Chip lined by human lung alveolar epithelial cells interfaced with lung capillary cells to recreate the alveolar-capillary interface in vitro, the researchers recapitulated many of the hallmarks of RILI, including radiation-induced DNA damage in lung tissue, cell-specific changes in gene expression, inflammation, and injury to both the lung epithelial cells and blood vessel-lining endothelial cells. By also evaluating the potential of two drugs to suppress the effects of acute RILI, the researchers demonstrated their model’s capabilities as an advanced, human-relevant, preclinical, drug discovery platform.

Boston universityUnited statesMassachusetts institute of technologyTufts universityUniversity of massachusetts medical schoolSpaulding rehabilitation hospitalDonald ingberBenjamin boettnerRobert mannixAmanda jiangAmy wenSean hallEmilia javorskyQueeny dasguptaFarber cancer instituteDrug administration

Adding immunity to human kidney-on-a-chip adv

T cell bispecific antibodies (TCBs) are an emerging class of immunotherapeutics with several TCBs approved by the FDA for the treatment of leukemias, lymphomas, and myelomas. TCBs label tumor cells with one of their ends, and attract immune cells with another end to coerce them into tumor cell killing. However, one major challenge in the development of TCBs are “on-target, off-tumor” toxicities at sites in the body that also express TCB-targeted antigens. A new collaboration of Jennifer Lewis’ group and researchers from the Roche Innovation Centers in Switzerland and Germany now created an immune-infiltrated human kidney organoid-on-chip model that allows kidney toxicity of TCBs.

United statesSpaulding rehabilitation hospitalTufts universityMassachusetts institute of technologyUniversity of massachusetts medical schoolBoston universityBenjamin boettnerAntje christine walzMariana mataKen hiratsukaJennifer lewisKatharina krollDonald ingberVirginie micallefKimberly homanJoseph bonventre

Adding immunity to human kidney-on-a-chip adv

Adding immunity to human kidney-on-a-chip adv
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

United statesMassachusetts institute of technologyUniversity of massachusetts medical schoolSpaulding rehabilitation hospitalBoston universityTufts universityKimberly homanJennifer lewisKatharina krollJennifer lewiVirginie micallefJoseph bonventreMariana mataMarcel gruberAnnie moisanAlejandro carpy

Moving the needle on monitoring skin cancer

Moving the needle on monitoring skin cancer
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

Tufts universityUnited statesBoston universitySpaulding rehabilitation hospitalUniversity of massachusetts medical schoolMassachusetts institute of technologyDavid waltMichael lewandowskiMariana alonsoAlexander cryerDaniel dahisRushdy ahmadNatalie artziHaim azhariMichelle dionDonald ingber