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A microfluidic organ chip model of the human blood-brain barrier for development of brain-targeting therapeutics

A microfluidic organ chip model of the human blood-brain barrier for development of brain-targeting therapeutics
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United statesSouth koreaRepublic of koreaEric shustaNur mustafaogluDonald ingberJames gormanVascular biology program at boston children hospitalNature communicationsBrain targeting programEngineering at university of wisconsinWyss instituteHarvard wyss institute for biologically inspired engineeringWyss institute at harvard universityProfessor at ulsan national institute of scienceTechnology team

Boosting CAR-T cell therapies from under the

Boosting CAR-T cell therapies from under the
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Tufts universityUnited statesSpaulding rehabilitation hospitalUniversity of massachusetts medical schoolBoston universityMassachusetts institute of technologyMiguel sobralKwasi adu berchieRobertp pinkasDavid zhangJoshua brockmanYutong liuDavid mooneyYoav binenbaumDonald ingberDave mooney

Boosting CAR-T cell therapies from under the skin

CAR-T cell therapies are transforming the treatment of previously incurable blood cancers, but a large proportion of patients still responds only poorly or not at all to them, calling for new strategies to overcome this challenge. Now, a research team has developed a simple intervention in the form of a biodegradable scaffold material called T-cell enhancing scaffolds (TES) that can be locally injected under the skin and used to restimulate CAR-T cells after their administration. This increased their therapeutic efficacy and significantly curbed tumor growth and prolonged animal survival in an aggressive mouse lymphoma model.

United statesMiguel sobralRobertp pinkasYoav binenbaumYutong liuDonald ingberDave mooneyDavid mooneyDavid zhangJoshua brockmanKwasi adu berchieDrug administrationHarvard johna paulson school of engineeringWyss institute at harvard universityNational institutes of healthUniversity of wisconsin

Microfluidic Organ Chip Models Human Cervix, Boosts Women s Health

Microfluidic Organ Chip Models Human Cervix, Boosts Women s Health
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United statesZohreh izadifarSiyu chenYixuan xieAnna stejskalovaDonald ingberBenjamin boettnerSarah gilpinGirja goyalAdama sesayBogdan budnikAakanksha gulatiErin dohertyViktor horvathNina lograndeCarlito lebrilla

Using static electricity, RoboBees can land and stick to surfaces

New system extends the lives of flying microrobots

Kevin maRobert woodMoritz grauleHarvard johna paulson school of engineeringWyss instituteHarvard microrobotics labHarvard johnApplied sciencesBiologically inspired engineeringCharles river professor