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<p>Researchers have developed a human&nbsp;<em>in vitro</em>&nbsp;model that closely mimics the complexities of radiation-induced lung injury (RILI) and radiation dose sensitivity of the human lung. Using a previously developed microfluidic human Lung Alveolus Chip lined by human lung alveolar epithelial cells interfaced with lung capillary cells to recreate the alveolar-capillary interface&nbsp;<em>in vitro</em>, the researchers recapitulated many of the hallmarks of RILI, including radiation-induced DNA damage in lung tissue, cell-specific changes in gene expression, inflammation, and injury to both the lung epithelial cells and blood vessel-lining endothelial cells.&nbsp;By also evaluating the potential of&nbsp;two drugs to suppress the effects of acute RILI, the researchers demonstrated their model&rsquo;s capabilities as an advanced, human-relevant, preclinical, drug discovery platform.</p>

Boston universityUnited statesMassachusetts institute of technologyTufts universityUniversity of massachusetts medical schoolSpaulding rehabilitation hospitalDonald ingberBenjamin boettnerRobert mannixAmanda jiangAmy wenSean hallEmilia javorskyQueeny dasguptaFarber cancer instituteDrug administration