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The Lee index: Risk of perioperative cardiac events [Classics Series]

1. The Lee index is a prospectively validated model that predicts the risk of a cardiac event in patients undergoing noncardiac surgery. 2. The six independent predictors are as follows: 1) high-risk surgery, 2) history of ischemic heart disease, 3) history of congestive heart failure, 4) history of cerebrovascular disease, 5) preoperative treatment with insulin,

The ORACLE trial: Antibiotics for preterm, prelabor rupture of membranes [Classics Series]

1. Among infants born to women with preterm, premature rupture of membranes, those whose mothers were randomized to treatment with erythromycin experienced a lower incidence of adverse neonatal outcomes and prolongation of pregnancy compared to the placebo group. Original Date of Publication: March 2001 Study Rundown: Preterm, premature (prelabor) rupture of membranes (PPROM) is a

The Child-Pugh score: Prognosis in chronic liver disease and cirrhosis [Classics Series]

1. The Child-Pugh score consists of five clinical features and is used to assess the prognosis of chronic liver disease and cirrhosis. 2. The Child-Pugh score was originally developed in 1973 to predict surgical outcomes in patients presenting with bleeding esophageal varices. 3. The score is used with the Model for End-Stage Liver Disease (MELD)

The ABCD2 score: Risk of stroke after Transient Ischemic Attack (TIA) [Classics Series]

1. The ABCD2 score is a validated, seven-point, risk-stratification tool to identify patients at high risk of stroke following a transient ischemic attack (TIA). 2. Patients with scores ≥4 are at considerably higher risk of stroke in the 2-day period following a TIA, and may potentially require urgent intervention as inpatients. Original Date of Publication:

The ACCORD trial: Intensive glucose control associated with increased mortality [Classics Series]

1. Previous studies suggest that intensive blood glucose control reduces the risk of microvascular complications, though questions remained regarding the impact on macrovascular complications and mortality. 2. This study found that targeting HbA1c

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