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The NICE-SUGAR trial: Intensive glycemic control harmful in the ICU [Classics Series]

Intensive glucose control to target 81-108 mg/dL significantly increased 90-day mortality compared to conventional glucose control to target ≤180 mg/dL.

The Lee index: Risk of perioperative cardiac events [Classics Series]

1. The Lee index is a prospectively validated model that predicts the risk of a cardiac event in patients undergoing noncardiac surgery. 2. The six independent predictors are as follows: 1) high-risk surgery, 2) history of ischemic heart disease, 3) history of congestive heart failure, 4) history of cerebrovascular disease, 5) preoperative treatment with insulin,

The ORACLE trial: Antibiotics for preterm, prelabor rupture of membranes [Classics Series]

1. Among infants born to women with preterm, premature rupture of membranes, those whose mothers were randomized to treatment with erythromycin experienced a lower incidence of adverse neonatal outcomes and prolongation of pregnancy compared to the placebo group. Original Date of Publication: March 2001 Study Rundown: Preterm, premature (prelabor) rupture of membranes (PPROM) is a

The Child-Pugh score: Prognosis in chronic liver disease and cirrhosis [Classics Series]

1. The Child-Pugh score consists of five clinical features and is used to assess the prognosis of chronic liver disease and cirrhosis. 2. The Child-Pugh score was originally developed in 1973 to predict surgical outcomes in patients presenting with bleeding esophageal varices. 3. The score is used with the Model for End-Stage Liver Disease (MELD)

The ABCD2 score: Risk of stroke after Transient Ischemic Attack (TIA) [Classics Series]

1. The ABCD2 score is a validated, seven-point, risk-stratification tool to identify patients at high risk of stroke following a transient ischemic attack (TIA). 2. Patients with scores ≥4 are at considerably higher risk of stroke in the 2-day period following a TIA, and may potentially require urgent intervention as inpatients. Original Date of Publication:

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