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 E-Mail A pioneering new study led by UCL scientists has revealed, for the first time, a layer of genetic material involved in controlling the production of tau; a protein which plays a critical role in serious degenerative conditions, such as Parkinson s and Alzheimer s disease. The international research, conducted in mice and cells, also revealed this material is part of a larger family of non-coding genes which control and regulate other similar brain proteins, such as beta-amyloid associated with Alzheimer s and alpha-synuclein implicated in Parkinson s disease and Lewy body dementia. Researchers say the breakthrough findings, published in Nature, shed an important new light on how proteins linked to neurological conditions are produced and controlled, and could pave the way for new treatments for a wide range of dementia related diseases.

United kingdomDavid dexterUniversity of trentoKarolinska instituteQueen square institute of neurologyUnited kingdom dementia research instituteSt george university of londonResearch at parkinson united kingdomResearch councilFrancis crick instituteReta lila westonSquare instituteProfessor rohan de silvaAssociate directorReta lila weston trustWellcome trust