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Fresh insight into protein production inside brain cells could help tackle Parkinson s

E-Mail Wednesday 19 May 2021 - New research published today sheds important light on how the production of a key protein in the brain is controlled, which could pave the way for new treatments for a wide range of neurological conditions. In a study part-funded by Parkinson s UK, researchers investigated a section of genetic material known as antisense long non-coding RNA (lncRNA), which helps fine-tune the production of the protein tau inside brain cells. This precision in tau regulation is crucial for smooth functioning of the nerve cells. Understanding the mechanism which helps regulate tau production could be the key to developing better treatments for conditions including Parkinson s, Alzheimer s, corticobasal degeneration and progressive supranuclear palsy.

United kingdomDavid dexterRoberto simoneUniversity college londonUniversity of trentoKarolinska instituteFrancis crick instituteResearch at parkinson united kingdomProfessor rohan de silvaAssociate directorParkinsons diseaseஒன்றுபட்டது கிஂக்டம்டேவிட் டெக்ஸ்டர்ரொபெர்டோ சிமோன்பல்கலைக்கழகம் கல்லூரி லண்டன்பல்கலைக்கழகம் ஆஃப் ட்ரெண்டோ

New insight into protein production in brain could help tackle dementia

E-Mail A pioneering new study led by UCL scientists has revealed, for the first time, a layer of genetic material involved in controlling the production of tau; a protein which plays a critical role in serious degenerative conditions, such as Parkinson s and Alzheimer s disease. The international research, conducted in mice and cells, also revealed this material is part of a larger family of non-coding genes which control and regulate other similar brain proteins, such as beta-amyloid associated with Alzheimer s and alpha-synuclein implicated in Parkinson s disease and Lewy body dementia. Researchers say the breakthrough findings, published in Nature, shed an important new light on how proteins linked to neurological conditions are produced and controlled, and could pave the way for new treatments for a wide range of dementia related diseases.

United kingdomDavid dexterUniversity of trentoKarolinska instituteQueen square institute of neurologyUnited kingdom dementia research instituteSt george university of londonResearch at parkinson united kingdomResearch councilFrancis crick instituteReta lila westonSquare instituteProfessor rohan de silvaAssociate directorReta lila weston trustWellcome trust

Study may lead to new treatments for a wide range of neurological conditions

Study may lead to new treatments for a wide range of neurological conditions
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David dexterRoberto simoneEmily hendersonUniversity college londonUniversity of trentoKarolinska instituteFrancis crick instituteResearch at parkinson united kingdomUnited kingdomProfessor rohan de silvaAssociate directorடேவிட் டெக்ஸ்டர்ரொபெர்டோ சிமோன்எமிலி ஹென்டர்சன்பல்கலைக்கழகம் கல்லூரி லண்டன்பல்கலைக்கழகம் ஆஃப் ட்ரெண்டோ

New insight into protein production in brain could help tackle dementia – study

New insight into protein production in brain could help tackle dementia – study
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Roberto simoneQueen square institute of neurologyResearch councilReta lila westonSquare instituteProfessor rohan de silvaReta lila weston trustWellcome trustMedical research councilUnited kingdomரொபெர்டோ சிமோன்ராணி சதுரம் நிறுவனம் ஆஃப் நரம்பியல்ஆராய்ச்சி சபைசதுரம் நிறுவனம்வெல்கம் நம்பிக்கைமருத்துவ ஆராய்ச்சி சபை

New insight into protein production in brain could help tackle dementia – study

New insight into protein production in brain could help tackle dementia – study
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