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1. In this randomized, double-blind, placebo-controlled trial, the use of once-weekly subcutaneous TG103 resulted in significant weight reduction at 12 weeks at all dosages. 2. It was deemed to be safe and effective, with pharmacokinetic findings in keeping with the weekly dose regimen recommended in preclinical studies. Evidence Rating Level: 1 (Excellent) Obesity, caused by
1. A multivariate predictive model was developed to help determine when a bone marrow sample would help distinguish between patients with monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM). 2. The model aimed to minimize unnecessary bone marrow sampling in this population. Evidence Rating Level: 2 (Good) Study Rundown: MGUS may be
1. In this randomized controlled trial, algorithmic identification based on electronic health records (EHRs) and practice facilitators did not reduce hospitalization rates among patients with chronic kidney disease (CKD). 2. Among patients with an unknown ASCVD risk score, those deemed statin-eligible by the model were nearly twice as likely to have incident MACE. Evidence Rating
1. In this retrospective cohort study, enrollment in medical cannabis programs increased overall in the United States (US) between 2020 and 2022. 2. In jurisdictions with nonmedical adult-use laws, enrollment in medical access programs declined within this time frame. Evidence Rating Level: 2 (Good) Study Rundown: Despite the introduction and expansion of legal cannabis use