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Kawasaki Clues: Disease Most Likely Airborne, Not Contact- or Droplet-Transmitted

Kawasaki Clues: Disease Most Likely Airborne, Not Contact- or Droplet-Transmitted
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Study Results Raise Possibility of Liver Transplant as Tx Option for Advanced CRC Liver Metastasis

Apr 2, 2021 Increased overall survival compared with portal vein embolization, liver resection In a highly select group of patients with colorectal cancer and nonresectable liver metastases, high liver tumor load, and left-sided primary tumors, liver transplant brought about significantly higher overall survival (OS) rates compared with portal vein embolization (PVE) and liver resection. Thus, liver transplant may be a viable treatment option in future prospective studies of select patients with colorectal liver metastasis, researchers reported. Although liver resection is the standard of care in patients with colorectal cancer and liver metastasis, few patients qualify as candidates, according to researchers led by Svein Dueland, MD, PhD, of Oslo University Hospital, Norway, who had previously demonstrated significant differences in OS after liver transplant in patients with primary tumors located in the ascending colon compared with those with primary tumors in the rest of the c

Radiotherapy for SCLC: Proving the Feasibility of A Higher Dose

Mar 8, 2021 High-dose, accelerated radiotherapy brings better 2-year overall survival, with no added toxicity In patients with limited stage, small-cell lung cancer (SCLC), hyperfractionated, accelerated, twice-daily thoracic radiotherapy (60 Gy) was feasible, and higher doses brought about significant improvements in two-year and median overall survival compared with the standard dose and schedule (45 Gy), with no additional toxicities, according to a study published in “To our knowledge, the two-year overall survival in our trial is the highest reported in trials in limited stage SCLC, including all trials of high-dose, once-daily thoracic radiotherapy, and adds to the evidence suggesting that accelerated, hyperfractionated thoracic radiotherapy is the most effective approach in this disease,” wrote Bjørn Henning Grønberg, MD, of the Norwegian University of Science and Technology, Trondheim, Norway, and colleagues.

International PURE Study: High GI/Load Associated with Increased Risks of CVD, CV Death

Feb 25, 2021 Associations finally demonstrated in a large, diverse population Diets with a high glycemic index are associated with an increased risk of both cardiovascular disease (CVD) and death, according to results from the large, international Prospective Urban Rural Epidemiology (PURE) study, published in Previous studies on the associations between glycemic index and cardiovascular disease and risk have shown mixed results and have been primarily conducted in participants from high-income Western populations. To rectify this, David J.A. Jenkins, MD, PhD, of the University of Toronto, Ontario, Canada, and fellow PURE study investigators, conducted this study. “We have assessed the association between the glycemic index and cardiovascular disease and all-cause mortality in the large, international [PURE] study involving participants with a broad range of carbohydrate intakes and diverse dietary patterns. We hypothesized that such a study would be most likely to indicate th

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