Feb 24, 2021
Few drugs approved in U.S. accepted by England and Canada for coverage
The fate of investigational cancer therapies often depends upon which side of “the pond” is making the decision, a disconnect that is driven by the use of differing criteria and processes.
For example, the United States often approves cancer therapies using a fast-track process, while that accelerated approach is seldom used in England or Canada, according to two studies published in
JAMA Internal Medicine.
In the first study, Avi Cherla, MSc, of the London School of Economics and Political Science, London, U.K., and colleagues, sought to assess the agreement between European and FDA decisions regarding drugs qualifying for accelerated approval by the FDA.
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Feb 10, 2021
REALITY results show restrictive transfusions noninferior to liberal transfusions
Restrictive transfusion for patients with acute myocardial infarction (AMI) and anemia is noninferior to a liberal transfusion strategy in the incidence of major adverse cardiovascular events (MACE), according to results from the open-label, randomized Restrictive and Liberal Transfusion Strategies in Patients with Acute Myocardial Infarction (REALITY) trial.
“Anemia is common in patients with AMI and is associated with worse clinical outcomes. In theory, transfusion should increase oxygen delivery, which would argue for a liberal transfusion strategy in patients with acute myocardial ischemia. However, data suggest that oxygen delivery is not necessarily increased in patients receiving transfusions, due to red blood cell depletion in nitric oxide and 2,3-diphosphoglyceric acid during storage, and that, conversely, transfusion may increase platelet activation and aggregation and produc
Feb 11, 2021
Stick to guideline-based physical activity for improving cardiorespiratory fitness, diastolic function
High-intensity interval training (HIIT) is no better than moderate continuous training at improving peak oxygen consumption (VO
2) in patients with heart failure with preserved ejection fraction (HFpEF), although both did improve it, according to a recent study published in
Further, neither exercise regimen was more effective at improving peak VO
2 compared with guideline-based physical activity, and neither brought about clinically relevant changes in cardiorespiratory fitness, diastolic function, or natriuretic peptide levels after 3 or 12 months when compared with guideline-recommended physical activity, Martin Halle, MD, of the Technical University of Munich, Munich, Germany, and fellow researchers with the OptimEx-Clin Study Group reported.
Feb 5, 2021
Simple, inexpensive, and well-tolerated statins may protect against post-op adhesion-related complications
Statin use at the time of intra-abdominal surgery may reduce the risk of postoperative adhesion-related complications (ARCs) including small-bowel obstructions (SBO), the need for adhesiolysis, and even infertility secondary to adhesions according to results from a recent study published in
“More than 90% of patients develop adhesions after intra-abdominal surgery. Adhesion-related complications (ARCs) occur in up to 5% of patients undergoing these operations and are responsible for significant morbidity and mortality. More than 70% of small-bowel obstructions (SBOs) and 40% of cases of infertility are secondary to adhesions. Future operations in patients with adhesions are associated with inadvertent enterotomy rates of 10% to 20%, resulting in an estimated mortality of 13%,” according to lead author Frank I. Scott, MD, MSCE, of the University of Colorad
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