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Scientists identify how dietary restriction slows brain aging and increases lifespan

Scientists identify how dietary restriction slows brain aging and increases lifespan
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Lisa ellerbyJuvify bioPankaj kapahiKenneth wilsonNature communicationsBuck professor pankaj kapahiBuck professor lisa ellerby

Buck Institute receives $14 million NIH grant to focus on one of the major drivers of aging

Buck Institute receives $14 million NIH grant to focus on one of the major drivers of aging
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United statesEric verdinJudith campisiLisa ellerbyEmily hendersonBuck instituteLisa ellerby phdBuck president

Researchers identify new approach to clear toxic Huntingtin protein

Researchers world-wide are focused on clearing the toxic mutant Huntingtin protein that leads to neuronal cell death and systemic dysfunction in Huntington's disease (HD), a devastating, incurable, progressive neurodegenerative genetic disorder.

Barbara bailusFelix hauschLisa ellerbyBuck institute ellerbyTechnical university in darmstadtBuck instituteKeck graduate institute in claremontStudy directorAssistant professorKeck graduate instituteTechnical universityEll deathGenetic disorderHuntington 39s diseaseதொழில்நுட்ப பல்கலைக்கழகம் இல் டர்ம்ஸ்டட்ட்பக் நிறுவனம்

Modulating rapamycin target protein promotes autophagy, lowering toxic Huntingtin protein

Recent failed clinical trials of a drug designed to clear the mutant Huntingtin protein that causes Huntington s disease (HD) heightens the need for new approaches for the devastating, incurable, progressive neurodegenerative genetic disorder. Scientists at the Buck Institute have found that the targeting the protein called FK506-binding protein 51 or FKBP51 promotes the clearing of those toxic proteins via autophagy, a natural process whereby cells recycle damaged proteins and mitochondria and use them for nutrition.

Jesse simonsSwati naphadeMichellee ehrlichNingzhe zhangKuruwitage lakshika madushaniStephen scheelerFeliz hauschTechnische universitat darmstadtKathrineh schreiberJordi creus muncunillFelix hauschMariaa sanchezAlejandro lopez ramirezBarbara bailusBrian kennedyLisa ellerby