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Hessen: TU Darmstadt: Offene Tür verursacht Großeinsatz

Hessen: TU Darmstadt: Offene Tür verursacht Großeinsatz
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Researchers identify new approach to clear toxic Huntingtin protein

Modulating rapamycin target protein promotes autophagy, lowering toxic Huntingtin protein

Recent failed clinical trials of a drug designed to clear the mutant Huntingtin protein that causes Huntington s disease (HD) heightens the need for new approaches for the devastating, incurable, progressive neurodegenerative genetic disorder. Scientists at the Buck Institute have found that the targeting the protein called FK506-binding protein 51 or FKBP51 promotes the clearing of those toxic proteins via autophagy, a natural process whereby cells recycle damaged proteins and mitochondria and use them for nutrition.

Most Importantly, I Can Stimulate Processes : In conversation with Christoph Hesse

Copy Vladimir Belogolovsky speaks with Christoph Hesse over Skype between New York and his office in Korbach, Germany to discuss his pioneering projects and why working in the countryside is relevant. Christoph Hesse (b. 1977) grew up on a farm in a small village of just over 200 residents, Referinghausen in the low forested mountain range in Sauerland in Central Germany. He graduated from ETH Zurich in 2004 and GSD in 2007 and established Christoph Hesse Architects in 2008 in a small town Korbach near Kassel, home of the documenta exhibitions of contemporary art. Hesse has been teaching at Harvard University, Technische Universität Darmstadt, Ho Chi Minh City University of Architecture in Saigon, Cairo University, and Universität Kassel. His practice currently employs an international team of 15 people. In 2018, a branch office was set up in Berlin.

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