A gene concentrated in microglia has been identified as a mechanism to the inflammation in the brain that is a key factor in the development of Alzheimer’s disease.
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A new study links a gene concentrated in the brain's cleanup cells, known as microglia, to the inflammation that has increasingly emerged as a key mechanism contributing to Alzheimer's disease.
Inflammation has increasingly been identified as a significant factor contributing to Alzheimer s disease, and a recent study relates this inflammation to a gene abundant in the brain s clearing cells, known as microglia
Recent failed clinical trials of a drug designed to clear the mutant Huntingtin protein that causes Huntington s disease (HD) heightens the need for new approaches for the devastating, incurable, progressive neurodegenerative genetic disorder. Scientists at the Buck Institute have found that the targeting the protein called FK506-binding protein 51 or FKBP51 promotes the clearing of those toxic proteins via autophagy, a natural process whereby cells recycle damaged proteins and mitochondria and use them for nutrition.