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Scientists discover how to prevent T cell exhaustion to maintain the fight against cancer

When faced with a formidable foe for months on end, the immune system's T cells begin to tire. Whether fighting a cancer or a chronic infection, they become less effective over time, a phenomenon dubbed "T cell exhaustion" by scientists.

Julia belkJulia carnevaleSantosh vardhanaAnsuman satpathyEmily hendersonAlex marsonDepartment of pathologyInstitute of genomic immunologyStanford school of medicineStanford universityMemorial sloan kettering cancer centerGladstone institutesGenomic immunologyStanford schoolCrystal mackallImmune system

Once Science Fiction, Gene Editing Is Now a Looming Reality

The prospect of erasing some disabilities and perceived deficiencies hovers at the margins of what people consider ethically acceptable.

New yorkUnited statesStanford universitySan franciscoMeghan halleyAmanda grysLizzie nattingerEllen grysAlex marsonDana carrollFabrizio piroloEthan weissKatie hafnerMatthew lyonRuthie weissUniversity of california

A comprehensive rule book for the design of safe and efficient therapeutic cells

Therapies based on engineered immune cells have recently emerged as a promising approach in the treatment of cancer.

Kole roybalIowis zhuRaymond liuEmily hendersonDepartment of microbiologyInstitute of genomic immunologyRoybal labParker institute for cancer immunotherapyGladstone institutesGenomic immunologyParker instituteArsenal bioAncer immunotherapyOvarian cancer

How Obesity Can Rewire Immune System and Response to Immunotherapy – and How to Change That

How Obesity Can Rewire Immune System and Response to Immunotherapy – and How to Change That
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United statesSalk instituteNew south walesSan franciscoCaroline whittyMichael petersMarlys fassettEmma guttman yasskySarah gayerZhongmei liRichard galloWandi zhuLaura crotty alexanderNoah berger sagar bapatAlex marsonZewen jiang

How Obesity Can Rewire the Immune System and the Response to Immunotherapy--and How to Change That

/PRNewswire/ When mice with atopic dermatitis a common type of allergic skin inflammation are treated with drugs that target the immune system, their.

United statesSalk instituteNew south walesSan franciscoChan zuckerberg biohubCaroline whittyMichael petersMarlys fassettEmma guttman yasskySarah gayerZhongmei liRichard galloWandi zhuLaura crotty alexanderJulie langelierAlex marson