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Transcripts For CSPAN3 Politics Public Policy Today 20140717

Thought about todays hearing as it relates to cdc, it is this. With the recent incidents, we recognize the pattern at cdc where we need to greatly improve the culture of safety and i am overseeing sweeping measures to improve that culture of safety. Cdc works 24 7 and our scientists protect americans from threats, including naturally occurring threats like ebola and mers and drug resistant bacteria such as anthrax. But we must do that work more safely and we will. Theres a recap of the recent incidents that summarized in our report which has been completed and were just at the outset of our investigation of the influenza contamination. Id be pleased to go through the two diagrams weve provided to the subcommittee which outlined what we know to date. But in brief, the anthrax incident shows deeply troubling problems. A lack of proper protocol, incorrect inactivation procedures. Failure to ensure that we were transferring materials that were sterile when we thought they were sterile. Use

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Transcripts For CSPAN3 Politics Public Policy Today 20140804

Political participation as two of his principles while at the same time the president has kept afghanistans first lady hidden from the eyes of the world for the most part. Do you think he fears that its going to ignite the same protests and reactions from the tribal leaders in the conservative sections of the society . I will answer in the following way. The best solution would have been if the afghans could have solved this themselves. Clear in his immigration speech in 2009, karzai said i want to organize the process. That was after the interference trying to unseat him at the time. Now that didnt work. That didnt work and, therefore, i believe that the visit by john kerry. I admire and respect the fact that he went there, sat down and came to what for me is im going to say the only obvious solution when it comes to the counting. If you disagree on how much to count, count it all, huh . But kerrys handson diplomacy in this respect is admirable. I think its admirable. In 2009 when he

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Transcripts For FOXNEWSW Red Eye 20140903

Lets welcome our guests. She is cheekier than a squirrel acting nuts in the wenter. I am here with joanne nosuchunsky. And tvs andy levey. And he once lost a National Talent competition to a dog. It is not a jock. It is just it is not a joke. And i hope she has good martin sheen stories. Fox News National security analyst kt mcfarland. A block. The lede. Thats the firs story. What we saw of jla left us in awe. Nude pics were posted of Jennifer Lawrence sadly not jude law. And the fbi has gun an investigation into the investigation of several i cloud accounts with nude photos. Dozens of private naked pics, not seen here of stars including Jennifer Lawrence and kate upton and Mary Elizabeth surfaced on the web as they do. Some of the victims said the photos were fake while others confirmed the authorities have been contacted and they will prosecute anyone who will post the stolen photos. There was a quote, celebs make it harder to get nude pics on your computer by not putting the nude pi

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$1M grant to help prepare students for impactful careers in the arts

$1M grant to help prepare students for impactful careers in the arts
ucsc.edu - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from ucsc.edu Daily Mail and Mail on Sunday newspapers.

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Image-lab

The CRL5–SPSB3 ubiquitin ligase targets nuclear cGAS for degradation

Cyclic GMP-AMP synthase (cGAS) senses aberrant DNA during infection, cancer and inflammatory disease, and initiates potent innate immune responses through the synthesis of 2′3′-cyclic GMP-AMP (cGAMP)1–7. The indiscriminate activity of cGAS towards DNA demands tight regulatory mechanisms that are necessary to maintain cell and tissue homeostasis under normal conditions. Inside the cell nucleus, anchoring to nucleosomes and competition with chromatin architectural proteins jointly prohibit cGAS activation by genomic DNA8–15. However, the fate of nuclear cGAS and its role in cell physiology remains unclear. Here we show that the ubiquitin proteasomal system (UPS) degrades nuclear cGAS in cycling cells. We identify SPSB3 as the cGAS-targeting substrate receptor that associates with the cullin–RING ubiquitin ligase 5 (CRL5) complex to ligate ubiquitin onto nuclear cGAS. A cryo-electron microscopy structure of nucleosome-bound cGAS in a complex

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