Researchers from the University of Western Ontario in Canada have found that an AI tool can predict who will recover from serious brain injury 80% of the t | Neuroscience
1. In this randomized controlled trial, for adults with major trauma or trauma-induced coagulopathy, prehospital administration of tranexamic acid did not improve outcomes at six months. 2. There were no differences in the number of adverse events between those patients who received tranexamic acid versus those who received a placebo. Evidence Rating Level: 1 (Excellent)
Longitudinal data show that people with traumatic brain injury continue to show improvement or to decline across a range of domains well beyond the traditional 12-month post-injury period.
Maintaining hypercapnia for the first 24 hours in comatose patients resuscitated after out-of-hospital cardiac arrest did not improve outcomes in a large, randomized trial.
Objective
Accidental traumatic brain injury (TBI) can lead to severe complications such as endocrine abnormalities and long-term morbidities and can negatively impact patient lives. These conditions are also associated with a high cost of treatment over a lifetime, a significant concern in low-to-middle-income countries (LMICs). In Pakistan, the prevalence of children with endocrine abnormalities secondary to TBI remains largely unexplored. We conducted a retrospective cross-sectional study to estimate the burden of endocrine abnormalities due to TBI among children in our population.
Methods
Twenty patients previously admitted with head injury between September and October 2019 were retrospectively reviewed with tests for baseline serum sodium, plasma osmolality, cortisol, adrenocorticotropin (ACTH), free thyroxine (fT4), growth hormone (GH), insulin growth factor-1 (IGF-1), follicle-stimulating hormone (FSH), luteinizing hormone (LH), thyroid-stimulating hormone (TSH), prolac