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Author summary • Human immunodeficiency virus (HIV) drug resistance has implications for antiretroviral treatment strategies and for containing the HIV pandemic because the development of HIV drug resistance leads to the requirement for antiretroviral drugs that may be less effective, less well-tolerated, and more expensive than those used in first-line regimens. • HIV drug resistance studies are designed to determine which HIV mutations are selected by antiretroviral drugs and, in turn, how these mutations affect antiretroviral drug susceptibility and response to future antiretroviral treatment regimens. • Such studies collectively form a vital knowledge base essential for monitoring global HIV drug resistance trends, interpreting HIV genotypic tests, and updating HIV treatment guidelines. • Although HIV drug resistance data are collected in many studies, such data are often not publicly shared, prompting the need to recommend best practices to encourage and st

United statesSherlock biosciencesAstra zenecaNational centerDanaher corporationUnited states centers for diseaseCenters for diseaseWorld health organizationData bankJanssen pharmaceuticalsAtea pharmaceuticalsShinogi pharmaceuticalsNational institute of allergyNational institutes genomic data sharingGilead sciencesNational institutes of health