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Frontiers | Systems Immunology Analysis Reveals the Contribution of Pulmonary and Extrapulmonary Tissues to the Immunopathogenesis of Severe COVID-19 Patients

2Luebeck Institute of Experimental Dermatology, University of Luebeck, Luebeck, Germany 3General Surgery Department, Tawam Hospital, SEHA, Al Ain, United Arab Emirates 4Center for Biotechnology, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates 5Department of Genetics and Molecular Biology, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates 6Department of Respiratory Medicine, Rashid Hospital, Dubai Health Authority, Dubai, United Arab Emirates 7Meakins-Christie Laboratories, McGill University, Montreal, QC, Canada 8Division of Surgery and Interventional Science, University College London, London, United Kingdom As one of the current global health conundrums, COVID-19 pandemic caused a dramatic increase of cases exceeding 79 million and 1.7 million deaths worldwide. Severe presentation of COVID-19 is characterized by cytokine storm and chronic inflammation resulting in multi-organ dysfunction. Currently, it is unclear whet

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