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Giving Immunotherapy Cells Resilience to Pass the Stress Test

T cells used in immunotherapy treatments can get exhausted and shut down by fighting cancer cells and tumors. Using a CRISPR-based edit on these cells’ genomes, researchers at UCSF and Gladstone Institutes have rendered the therapeutic cells more resilient against tumors.

United statesSan franciscoNupura kaleBence danielShane vedovaJulia belkShannon langeYan yi chenMarie luetke everslohWilliama nybergTheodorel rothZhongmei liEric shifrutScott koganBrooke prinzingDalia haydar

Non-viral CRISPR could overcome cell and gene therapy bottlenecks

Non-viral CRISPR could overcome cell and gene therapy bottlenecks
europeanpharmaceuticalreview.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from europeanpharmaceuticalreview.com Daily Mail and Mail on Sunday newspapers.

Justin eyquemJonathan esenstenAlex marsonInstitute of genomic immunologyUniversity of california san franciscoDivision of hematologyGladstone institutesCalifornia san franciscoGenomic immunologyNature biotechnologyBrian shy

Using the power of CRISPR to engineer better, stronger, longer-lived T cells

T cells used in immunotherapy treatments can get exhausted by the task of fighting cancer cells or get shutdown as they enter tumors.

Justin eyquemEric shifrutGiedre krenciuteJulia carnevaleAlan ashworthEmily hendersonAlex marsonJude children research hospitalInstitute of genomic immunologyDepartment of medicineTel aviv universityHelen diller family comprehensive cancer centerGladstone institutesGenomic immunologyHelen diller family comprehensive cancerTel aviv

New approach using CRISPR can engineer massive quantities of cells for therapeutic applications

A new variation of the CRISPR-Cas9 gene editing system makes it easier to re-engineer massive quantities of cells for therapeutic applications.

Justin eyquemJonathan esenstenJennifer doudnaEmily hendersonAlex marsonInstitute of genomic immunologyDivision of hematologyGladstone institutesGenomic immunologyNature biotechnologyBrian shyBlood cancerLiving cellsMultiple myelomaNext generation

High-yield CRISPR without viral vectors

High-yield CRISPR without viral vectors
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Justin eyquemJonathan esenstenJennifer doudnaAlex marsonInstitute of genomic immunologyDivision of hematologyGladstone institutesGenomic immunologyNature biotechnologyBrian shy