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Parkinson’s disease (PD) is the second most neurodegenerative disease in the world. T cell infiltration in the central nervous system (CNS) has provided insights that the peripheral immune cells participate in the pathogenesis of PD. However, the association between the peripheral immune system and CNS is remained to be elucidated. Here, we analyzed an incorporative substantial nigra expression data as well as another blood expression data using the CIBERSORT to obtain the 22 immune cells fraction and then explored the molecular function to identify the potential key immune cell types and genes of PD. We observed the proportions of naïve CD4 T cells, gamma delta T cells, resting NK cells, neutrophils in the blood, and regulatory T cells (Tregs) in the substantial nigra were significantly different between PD patients and healthy controls (HC). We identified p53-induced death domain protein 1 (PIDD1) as the hub gene of a Parkinson’s disease-related module. The set of neuron-specific genes was significantly different between PD and HC, and genes in the neuron-related module were enriched in the biological process about mitochondria and synapses. These results suggested that the fractions of naïve CD4 T cells, gamma delta T cells, resting natural killer (NK) cells, as well as neutrophils, may be used as a combined diagnostic marker in blood and Tregs in substantial nigra may be a potential therapeutic design target for PD.

Related Keywords

China ,Sanli ,Shaanxi ,United States ,Kyoto ,Japan ,Guangdong ,Jilin ,Chinese ,J Neuroimmune Pharmacol ,Felix Garza ,Tregs Rosenkranz ,Acta Neuropathol ,Guangdong Province Key Laboratory Of Fermentation ,National Natural Science Foundation Of China ,Graphpad Software ,Pearson ,Differential Gene Expression ,Supplementary Table ,Supplementary Figures ,Enrichment Analysis ,Kyoto Encyclopedia ,Graphpad Prism ,Supplementary Figure ,National Natural Science Foundation ,High Level Hospital Construction Project ,Guangdong Province Key Laboratory ,Enzyme Engineering ,Supplementary Material ,Med Abstract ,Crossref Full Text ,Meyer Zu Horste ,Parkinson 39s Disease ,Immune Cells ,Regs ,Idd1 ,Flood ,Substantia Nigra ,சீனா ,ஷாங்க்ஷி ,ஒன்றுபட்டது மாநிலங்களில் ,கியோட்டோ ,ஜப்பான் ,குவாங்டாங் ,சீன ,ஃபெலிக்ஸ் கர்ஜா ,தேசிய இயற்கை அறிவியல் அடித்தளம் ஆஃப் சீனா ,பியர்சன் ,வேறுபாடு கீந் வெளிப்பாடு ,துணை மேசை ,துணை புள்ளிவிவரங்கள் ,செறிவூட்டல் பகுப்பாய்வு ,கியோட்டோ கலைக்களஞ்சியம் ,துணை எண்ணிக்கை ,தேசிய இயற்கை அறிவியல் அடித்தளம் ,குவாங்டாங் மாகாணம் விசை ஆய்வகம் ,நொதி பொறியியல் ,துணை பொருள் ,மேட் ,ரெக்ஸ் ,

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