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Frontiers | Introgression of Maize Diversity for Drought Tolerance: Subtropical Maize Landraces as Source of New Positive Variants frontiersin.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from frontiersin.org Daily Mail and Mail on Sunday newspapers.
Parkinson’s disease (PD) is the second most neurodegenerative disease in the world. T cell infiltration in the central nervous system (CNS) has provided insights that the peripheral immune cells participate in the pathogenesis of PD. However, the association between the peripheral immune system and CNS is remained to be elucidated. Here, we analyzed an incorporative substantial nigra expression data as well as another blood expression data using the CIBERSORT to obtain the 22 immune cells fraction and then explored the molecular function to identify the potential key immune cell types and genes of PD. We observed the proportions of naïve CD4 T cells, gamma delta T cells, resting NK cells, neutrophils in the blood, and regulatory T cells (Tregs) in the substantial nigra were significantly different between PD patients and healthy controls (HC). We identified p53-induced death domain protein 1 (PIDD1) as the hub gene of a Parkinson’s disease-related module. The set of neuron-spe ....
Introduction: Pakistan ranks fifth in the globally estimated burden of Tuberculosis (TB) case incidence. Annually, a gap of 241,688 TB patients exists between estimated TB incidence and actual TB case notification in Pakistan. These undetected/missed TB cases initiate TB care from providers in the private healthcare system who are less motivated to notify patients to the national database that leads to significant under-detection of actual TB cases in the Pakistani community. To engage these private providers in reaching out to missing TB cases, a national implementation trial of the Public-Private Mix (PPM) model was cohesively launched by NTP Pakistan in 2014. The study aims to assess the implementation, contribution, and relative treatment outcomes of cohesively implemented PPM model in comparison to the non-PPM model. Methods: A retrospective record review of all forms (new and relapse) TB patients notified from July 2015 to June 2016 was conducted both for PPM- and non-PPM models ....
Despite the potentially huge contributions that coastal communities might make in marine resource management and sustainability, their participation in such efforts have only been recognized recently, particularly in Southeast Asia. Involving community perceptions can offer new insights for policy makers and resource managers and can elicit strong commitment and support from the communities themselves. This paper aims to understand perceptions of coastal communities of local environmental issues, specifically how these have developed over time, to understand expectations and perceptions of trends. Sixteen marine environmental issues were identified during stakeholder meetings in Palawan, Philippines. A co-developed survey was administered to 431 respondents from coastal communities in two municipalities (Taytay and Aborlan) and the city of Puerto Princesa in Palawan. The results show variation in perceptions and expectations between issues. We find that communities expect positive tren ....
Frontiers | State of the California Current 2019–2020: Back to the Future With Marine Heatwaves? frontiersin.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from frontiersin.org Daily Mail and Mail on Sunday newspapers.