[Full text] Cancer Cell–Membrane Biomimetic Boron Nitride Nanospheres for Ta

2School of Pharmaceutical Sciences, Jiangnan University, Wuxi, 214122, People’s Republic of China
Correspondence: Fuxue Chen
Tel/Fax +86-21-6613-5167
Purpose: Nanomaterial-based drug-delivery systems allowing for effective targeted delivery of smallmolecule chemodrugs to tumors have revolutionized cancer therapy. Recently, as novel nanomaterials with outstanding physicochemical properties, boron nitride nanospheres (BNs) have emerged as a promising candidate for drug delivery. However, poor dispersity and lack of tumor targeting severely limit further applications. In this study, cancer cell–membrane biomimetic BNs were designed for targeted anticancer drug delivery.
Methods: Cell membrane extracted from HeLa cells (HM) was used to encapsulate BNs by physical extrusion. Doxorubicin (Dox) was loaded onto HM-BNs as a model drug.

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