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New Quartet nanocage vaccine shows promise against coronavirus variants

New Quartet nanocage vaccine shows promise against coronavirus variants
news-medical.net - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from news-medical.net Daily Mail and Mail on Sunday newspapers.

Nature Nanotechnology , Quartet Nanocages , Alternate Multiviral Quartet , No Linker Quartet Nanocage , Quartet Nanocage , Homotypic Nanocage , Dual Quartet Nanocage ,

TSPAN8+ myofibroblastic cancer–associated fibroblasts promote chemoresistance in patients with breast cancer

TSPAN8+ myofibroblastic cancer–associated fibroblasts promote chemoresistance in patients with breast cancer
science.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from science.org Daily Mail and Mail on Sunday newspapers.

San Diego , United States , Matrigel Corning , Innovative Research Team Of High , National Natural Science Funds , Corning Incorporated , Human Ethics Committee Of Shanghai , National Key Rd Program Of China , Waters Corporation , Technology Innovation Action Plan , Shanghai General , American Type Culture , Thermo Fisher Scientific , Gene Ontology , Kyoto Encyclopedia , Thermo Fisher Scientific Acclaim Pepmap , Matrix Science , Human Ethics Committee , Shanghai General Hospital , Shanghai Jiao Tong University School , Alexa Fluor , Opal Polaris , Color Manual , Spectrum Labs , Graphpad Prism , National Key Rd Program ,

The HEAT repeat protein HPO-27 is a lysosome fission factor

Lysosomes are degradation and signalling centres crucial for homeostasis, development and ageing1. To meet diverse cellular demands, lysosomes remodel their morphology and function through constant fusion and fission2,3. Little is known about the molecular basis of fission. Here we identify HPO-27, a conserved HEAT repeat protein, as a lysosome scission factor in Caenorhabditis elegans. Loss of HPO-27 impairs lysosome fission and leads to an excessive tubular network that ultimately collapses. HPO-27 and its human homologue MROH1 are recruited to lysosomes by RAB-7 and enriched at scission sites. Super-resolution imaging, negative-staining electron microscopy and in vitro reconstitution assays reveal that HPO-27 and MROH1 self-assemble to mediate the constriction and scission of lysosomal tubules in worms and mammalian cells, respectively, and assemble to sever supported membrane tubes in vitro. Loss of HPO-27 affects lysosomal morphology, integrity and degradation activity, which impa ....

United States , Lysotracker Red , Magic Red , Lysotracker Blue Stained ,

The CRL5–SPSB3 ubiquitin ligase targets nuclear cGAS for degradation

Cyclic GMP-AMP synthase (cGAS) senses aberrant DNA during infection, cancer and inflammatory disease, and initiates potent innate immune responses through the synthesis of 2′3′-cyclic GMP-AMP (cGAMP)1–7. The indiscriminate activity of cGAS towards DNA demands tight regulatory mechanisms that are necessary to maintain cell and tissue homeostasis under normal conditions. Inside the cell nucleus, anchoring to nucleosomes and competition with chromatin architectural proteins jointly prohibit cGAS activation by genomic DNA8–15. However, the fate of nuclear cGAS and its role in cell physiology remains unclear. Here we show that the ubiquitin proteasomal system (UPS) degrades nuclear cGAS in cycling cells. We identify SPSB3 as the cGAS-targeting substrate receptor that associates with the cullin–RING ubiquitin ligase 5 (CRL5) complex to ligate ubiquitin onto nuclear cGAS. A cryo-electron microscopy structure of nucleosome-bound cGAS in a complex ....

Cytiva Akt , Lipofectamine Rnai , Jackson Immunoresearch , Microplates Perkin Elmer , Q Exactive Orbitrap , Phenoplate Perkinelmer , Proteome Software , Cell Signaling Technology , Electron Microscopy Sciences , Image Lab Software , Ge Healthcare Life Sciences , Carl Zeiss , Cell Biologics , Thermo Fisher Scientific , Supplementary Table , Thermo Fisher , Select Human Ubiquitin , Life Sciences , Perkin Elmer , Life Technologies , Omplete Protease Inhibitor Cocktail , Alexa Fluor , Santa Cruz , Click It Edu Imaging Kit , Mini Kit , Trans Blot Turbo ,

The kinase PLK1 promotes the development of Kras/Tp53-mutant lung adenocarcinoma through transcriptional activation of the receptor RET

The kinase PLK1 promotes the development of Kras/Tp53-mutant lung adenocarcinoma through transcriptional activation of the receptor RET
science.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from science.org Daily Mail and Mail on Sunday newspapers.

E Immunoblotting Kppc , Consortium For The Molecular Classification , Drug Administration , Cancer Genome Atlas , Challenge Consortium , Molecular Classification , Junn Terminal ,