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2School of Pharmaceutical Sciences, Jiangnan University, Wuxi, 214122, People’s Republic of China Correspondence: Fuxue Chen Tel/Fax +86-21-6613-5167 Purpose: Nanomaterial-based drug-delivery systems allowing for effective targeted delivery of smallmolecule chemodrugs to tumors have revolutionized cancer therapy. Recently, as novel nanomaterials with outstanding physicochemical properties, boron nitride nanospheres (BNs) have emerged as a promising candidate for drug delivery. However, poor dispersity and lack of tumor targeting severely limit further applications. In this study, cancer cell–membrane biomimetic BNs were designed for targeted anticancer drug delivery. Methods: Cell membrane extracted from HeLa cells (HM) was used to encapsulate BNs by physical extrusion. Doxorubicin (Dox) was loaded onto HM-BNs as a model drug. ....
Joe Raedle/Getty Images Uncovering and explaining how our digital world is changing and changing us. As vaccines are distributed around the world, an effective end to the Covid-19 pandemic seems to be on the horizon. There’s a new vaccine from Johnson & Johnson now being delivered, with supplies soon to be boosted by a deal with the pharmaceuticals giant Merck. President Biden now says the United States will have enough doses for every American by the end of May. But still, many still want to know why there aren’t more shots to go around right now. Here’s part of the answer: We’re still racing to make a special type of lipid, a relatively unknown but critical component of the vaccines being manufactured by Moderna and Pfizer/BioNTech. These vaccines use messenger RNA, the genetic component commonly known as mRNA that instructs cells to make proteins, which in turn teach the human body how to fight the virus that causes Covid-19. ....