The estimated value of the seized drugs is $160,000.
"Our information suggested these suspects were trafficking drugs in the region, and also supplying methamphetamine and fentanyl toward Medicine Hat and Lethbridge," said Staff Sgt. Kelsey Fraser of ALERT Medicine Hat in a statement.
Four residents of Didsbury were arrested and charged in connection with the investigation. Two residents of Medicine Hat were later arrested in Nanton.
Three people —35-year-old Ryan Riley and 32-year-old Lori Ehrler of Medicine Hat, and 53-year-old Edward Nicholson of Didsbury— have been charged with possession of drugs for the purpose of trafficking.
Nicholson also faces 11 firearms-related offences and a charge of possession of proceeds of crime.