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Harvard Researchers Elucidate Relationship Between Stress and Hair Loss | News


Harvard researchers have identified a mechanism explaining how chronic stress may lead to hair loss, according to a study published in Nature last month.
Researchers at Harvard, MIT, Massachusetts General Hospital, Icahn School of Medicine at Mount Sinai in New York, and University Hospital Würzburg in Germany collaborated on the study, which was helmed by Ya-Chieh Hsu, a biology professor at Harvard and faculty member at the Harvard Stem Cell Institute.
The study found the stress hormone corticosterone inhibited hair follicle stem cell activity and hair growth in mice. The researchers reported that when corticosterone levels were low in mice, their hair follicle stem cells regenerated much more frequently. However, when corticosterone levels were high due to chronic stress, the hair follicles entered a dormant phase. ....

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Kungl. Vetenskapsakademien: New knowledge about a cancer pharmaceutical led to the Sjöberg Prize


Kungl. Vetenskapsakademien: New knowledge about a cancer pharmaceutical led to the Sjöberg Prize
MALMÖ, Sweden, Feb. 15, 2021 /PRNewswire/
Benjamin L. Ebert, USA, receives this year s Sjöberg Prize, worth one million US dollars, for his research into how lenalidomide works as a treatment for blood cancer. His discovery of the mechanism that promotes protein breakdown in cancer cells may be vitally important to the future development of new pharmaceuticals.
The story of this pharmaceutical begins with a tragedy as, in the 1950s and 1960s, pregnant women with severe morning sickness were sometimes given thalidomide. This caused a range of birth defects and the medication was removed from the market. ....

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Discovery of 'adolescent' skeletal stem cells might someday help prevent osteoporosis


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IMAGE: Diana L. Carlone, Ph.D., of Boston Children s Hospital and the Harvard Stem Cell Institute.
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Credit: AlphaMed Press
Durham, NC - A new study reported in
STEM CELLS reveals a unique population of skeletal stem cells (SSCs) that function during the transitional period between rapid bone growth and bone maintenance. This discovery provides an opportunity to determine whether alterations in the SSCs pattern might affect bone formation, as well as helps us understand the physiological factors that regulate its timing.
This is particularly important given that anything that interferes with the proper development of bone mass during childhood and adolescence has long-lasting effects on our health, including the development of osteoporosis in adults, said corresponding author Diana L. Carlone, Ph.D., of Boston Children s Hospital and the Harvard Stem Cell Institute. ....

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