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Astronomy meets pathology to identify predictive biomarkers for cancer immunotherapy


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IMAGE: The AstroPath platform allows for the assessment of the level of expression of a given marker on individual cells, while maintaining information on their spatial location. Shown here is.
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Credit: Seyoun Park, Ph.D.
Pairing sky-mapping algorithms with advanced immunofluorescence imaging of cancer biopsies, researchers at The Mark Foundation Center for Advanced Genomics and Imaging at Johns Hopkins University and the Bloomberg~Kimmel Institute for Cancer Immunotherapy developed a robust platform to guide immunotherapy by predicting which cancers will respond to specific therapies targeting the immune system.
A new platform, called AstroPath, melds astronomic image analysis and mapping with pathology specimens to analyze microscopic images of tumors. ....

United States , Janis Taube , Charles Roberts , Evanj Lipson , Richard Wilton , Shlomit Jessel , Harriet Kluger , Evan Lipson , Inbalb Sander , Peter Nguyen , Jose Loyola , Qingfeng Zhu , Akoya Biosciences , Michele Cleary , Robert Anders , Suzannel Topalian , Elizabethm Jaffee , Ludmila Danilova , Elizabeth Engle , Margaret Eminizer , Daphne Wang , Sneha Berry , Aleksandra Ogurtsova , Angelo Demarzo , Haiying Xu , Roberta Anders ,

'Cellular chatter': Researchers aim to decode communications within a tumor


By William Weir
January 28, 2021
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Inside a tumor, chatter abounds. Multiple cell types are constantly communicating with each other, exchanging various types of information. Some are working together against the tumor, while others help the tumor grow. Researchers have a good handle on who the main players are, but it can be difficult to tell the good ones from the bad ones, and who’s communicating with whom. To make things even more complicated, sometimes good cells turn bad   and researchers don’t know why. ....

Marcus Bosenberg , Harriet Kluger , Susan Kaech , Kathryn Miller Jensen , Nomis Center , National Cancer Institute , Salk Institute , Yale Engineering , National Cancer , Rong Fan , Skin Cancer , Microbial Pathogenesis , Yale University , Press Releases , மார்கஸ் போசன்பெர்க் , ஹாரியட் கிழூகெர் , க்யாத்ரிந் மில்லர் ஜென்சன் , தேசிய புற்றுநோய் நிறுவனம் , சாள்க் நிறுவனம் , யேல் பொறியியல் , தேசிய புற்றுநோய் , றோங்க் விசிறி , தோல் புற்றுநோய் , யேல் பல்கலைக்கழகம் , ப்ரெஸ் வெளியீடுகள் ,