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What Are the Clinical Applications of Mass Spectrometry?

May 24 2021
Since German physicist Wilhelm Wien first laid the foundations of mass spectroscopy in the late 1800s, the analytical technique has evolved in leaps and bounds. Today, using ionisation to sort ions according to mass-to-charge ratio is one of the most reliable and accurate ways to identify chemical substances.
The analytical technique is used across a range of fields, including clinical research, pharmacology, food quality control, carbon dating and more. Want to know more about the clinical applications of mass spectrometry? Below, we explore some of the key areas where mass spectrometry is used to identify chemical substances and accelerate modern research. ....

Wilhelm Wien , Performance Liquid Chromatography ,

Study addresses glycosylation concerns in SARS-CoV-2 vaccine design

Study addresses glycosylation concerns in SARS-CoV-2 vaccine design
An international team of researchers has found that glycosylation patterns are conserved across the native spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – and the recombinant spike proteins made in laboratories for use in vaccines.
The spike protein, which SARS-CoV-2 uses to bind to and infect cells, is the main target of neutralizing antibodies following natural infection with the virus or vaccination.
A central tenet in vaccine design is the presentation of native-like antigens that will induce protective immunity.
The abundance of N-linked glycans across the SARS-CoV-2 spike protein is a potential source of heterogeneity between the many different vaccine candidates under investigation, says Max Crispin from the University of Southampton in the UK and colleagues. ....

United Kingdom , United States , Max Crispin , Sally Robertson , University Of Southampton , Coronavirus Disease Covid 19 , Sars Cov 2 , Corona Virus , Liquid Chromatography , Mass Spectrometry , Mers Cov , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , ஒன்றுபட்டது கிஂக்டம் , ஒன்றுபட்டது மாநிலங்களில் , அதிகபட்சம் மிருதுவான , சாலி ராபர்ட்சன் , பல்கலைக்கழகம் ஆஃப் சவுத்தாம்ப்டன் , கொரோனா வைரஸ் , நிறை ஸ்பெக்ட்ரோமெட்ரி , மேற்ச் கோவ் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

SARS-CoV-2 spike S1 subunit induces hypercoagulability

SARS-CoV-2 spike S1 subunit induces hypercoagulability
The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), is characterized by a range of clinical presentations. The vascular complications of the condition include a range of various coagulopathies that cause bleeding and thrombocytopenia or a hypercoagulable state. A new preprint research paper posted to the
medRxiv server describes the role of a fibrinogen-related protein in inducing these clinical features of COVID-19.
Cytokine dysregulation
Earlier research has shown a change in circulating cytokines involved in the inflammatory and coagulation pathways, indicating dysregulation of these biomarkers and the endothelium. These include fibrin(ogen), D-dimer, P-selectin and von Willebrand Factor (VWF), C-reactive protein (CRP), and other cytokines that bind to endothelial receptors. ....

Liji Thomas , Willebrand Factor , Sars Cov 2 , Corona Virus , Coronavirus Disease Covid 19 , C Reactive Protein , D Dimer , Mass Spectrometry , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , கொரோனா வைரஸ் , நிறை ஸ்பெக்ட்ரோமெட்ரி , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

The Role of D-Amino Acids in Humans

The Role of D-Amino Acids in Humans
Thought LeadersDaniel W. ArmstrongWelch Distinguished Professor, Dept. Chemistry
In this interview, Dr. Daniel Armstrong from the University of Texas at Arlington talks to News-Medical Life Sciences about his upcoming Pittcon presentation.
Could you start by telling us what D-amino acids are and what role they have in a healthy human body?
All living systems are made up of L-amino acids – we will call them left-handed amino acids - and D-amino acids are a mirror image of these. We will call those the right-handed amino acids. As with your right and left hand, one is a non-superimposable mirror image to the other. ....

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New nature communications publication by mann & theis groups harnesses the benefits of large-scale peptide collisional cross section (CCS) measurements and deep learning for 4D-proteomics

New Nature Communications publication by Mann & Theis Groups harnesses the benefits of large-scale peptide collisional cross section (CCS) measurements and deep learning for 4D-proteomics
Bruker Corporation today announces a seminal publication from the groups of Professors Matthias Mann and Fabian Theis in the journal Nature Communications with the title ‘Deep learning the collisional cross sections of the peptide universe from a million experimental values’ by Florian Meier et al. (doi.org/10.1038/s41467-021-21352-8).
Figure 1. Large-scale peptide collisional cross section (CCS) measurement with TIMS and PASEF. From Deep learning the collisional cross sections of the peptide universe from a million experimental values . (a) Workflow from extraction of whole-cell proteomes through digestion, fractionation, and chromatographic separation of each fraction. The TIMS-quadrupole TOF mass spectrometer was operated in PASEF mode. (b) Overview of the CCS dataset in this stud ....

Matthias Mann , Bruker Daltonicsmar , Gary Kruppa , Florian Meier , Fabian Theis , Nature Communications , University Of Copenhagen , Jena University Hospital , German Research Center , Max Planck Institute Of Biochemistry , Environmental Health , Novo Nordisk Foundation Center , Protein Research , Helmholtz Center Munich , Department Of Mathematics , Bruker Corporation , From Bruker Daltonicsmar , Professors Matthias Mann , Source Data , Professor Matthias Mann , Max Planck Institute , Professor Fabian Theis , Assistant Professor , Functional Proteomics , Pan Human , Bruker Vice President ,