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New nature communications publication by mann & theis groups harnesses the benefits of large-scale peptide collisional cross section (CCS) measurements and deep learning for 4D-proteomics


New Nature Communications publication by Mann & Theis Groups harnesses the benefits of large-scale peptide collisional cross section (CCS) measurements and deep learning for 4D-proteomics
Bruker Corporation today announces a seminal publication from the groups of Professors Matthias Mann and Fabian Theis in the journal Nature Communications with the title ‘Deep learning the collisional cross sections of the peptide universe from a million experimental values’ by Florian Meier et al. (doi.org/10.1038/s41467-021-21352-8).
Figure 1. Large-scale peptide collisional cross section (CCS) measurement with TIMS and PASEF. From Deep learning the collisional cross sections of the peptide universe from a million experimental values . (a) Workflow from extraction of whole-cell proteomes through digestion, fractionation, and chromatographic separation of each fraction. The TIMS-quadrupole TOF mass spectrometer was operated in PASEF mode. (b) Overview of the CCS dataset in this stud ....

Matthias Mann , Bruker Daltonicsmar , Gary Kruppa , Florian Meier , Fabian Theis , Nature Communications , University Of Copenhagen , Jena University Hospital , German Research Center , Max Planck Institute Of Biochemistry , Environmental Health , Novo Nordisk Foundation Center , Protein Research , Helmholtz Center Munich , Department Of Mathematics , Bruker Corporation , From Bruker Daltonicsmar , Professors Matthias Mann , Source Data , Professor Matthias Mann , Max Planck Institute , Professor Fabian Theis , Assistant Professor , Functional Proteomics , Pan Human , Bruker Vice President ,