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Controversial Stem Cell Therapy Has Helped Repair Injured Spinal Cords in 13 Patients 25 FEBRUARY 2021 Spinal cord injuries are sustained by hundreds of thousands of people every year, with many patients experiencing a significant and often permanent loss of movement and physical sensation resulting from nerve damage.
Beyond intensive physical rehabilitation programs – which can improve outcomes in some cases – treatment options are virtually non-existent. But new results from a phase 2 clinical trial offer fresh hope for remedies on the horizon. In an experimental collaboration by scientists in Japan and the US, 13 patients with spinal cord injuries (SCI) experienced a range of functional improvements in their condition after being treated with an intravenous infusion of their own stem cells, derived from their bone marrow. ....
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Scientists repair spinal cord injuries using patients’ stem cells 11 In a Phase II trial, all 13 patients who received an intravenous infusion of their own mesenchymal stem cells had improvements in neurological function six months later. In a new study, investigators demonstrated the feasibility, safety and efficacy of using a single intravenous infusion of mesenchymal stem cells (MSCs) to treat spinal cord injury (SCI) patients. According to the researchers, more than half of patients had substantial improvements in key functions, such as walking and using their hands, within weeks of the treatment. In the Phase II trial, 13 patients who had sustained non-penetrating SCI received an intravenous infusion of autologous (their own) MSCs cultured in auto-serum under Good Manufacturing Practice (GMP) production. The participants were then observed to see if their SCI symptoms – such as loss of motor function and coordination, sensory loss and bowel and bladder dys ....