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Yale scientists repair injured spinal cords using patients' own stem cells

By Lakshmi Bangalore
February 22, 2021
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Intravenous injection of bone marrow derived stem cells (MSCs) in patients with spinal cord injuries led to significant improvement in motor functions, researchers from Yale University and Japan report Feb. 18 in the Journal of Clinical Neurology and Neurosurgery.
For more than half of the patients, substantial improvements in key functions such as ability to walk, or to use their hands were observed within weeks of stem cell injection, the researchers report. No substantial side effects were reported.
The patients had sustained non-penetrating spinal cord injuries, in many cases from falls or minor trauma, several weeks prior to implantation of the stem cells. Their symptoms involved loss of motor function and coordination, sensory loss, as well as bowel and bladder dysfunction. The stem cel ....

Stepheng Waxman , Masanori Sasaki , Osamu Honmou , Jefferyd Kocsis , Yale University , Sapporo Medical University , Clinical Neurology , யேல் பல்கலைக்கழகம் , சப்போரோ மருத்துவ பல்கலைக்கழகம் , மருத்துவ நரம்பியல் ,

Scientists repair spinal cord injuries using patients' stem cells

Scientists repair spinal cord injuries using patients’ stem cells
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In a Phase II trial, all 13 patients who received an intravenous infusion of their own mesenchymal stem cells had improvements in neurological function six months later.
In a new study, investigators demonstrated the feasibility, safety and efficacy of using a single intravenous infusion of mesenchymal stem cells (MSCs) to treat spinal cord injury (SCI) patients. According to the researchers, more than half of patients had substantial improvements in key functions, such as walking and using their hands, within weeks of the treatment.
In the Phase II trial, 13 patients who had sustained non-penetrating SCI received an intravenous infusion of autologous (their own) MSCs cultured in auto-serum under Good Manufacturing Practice (GMP) production. The participants were then observed to see if their SCI symptoms – such as loss of motor function and coordination, sensory loss and bowel and bladder dys ....

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Scientists use patients' own stem cells to restore function after spinal cord injury

Scientists use patients' own stem cells to restore function after spinal cord injury
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Stepheng Waxman , Masanori Sasaki , Osamu Honmou , Jefferyd Kocsis , Emily Henderson , Yale University , Sapporo Medical University , Clinical Neurology , எமிலி ஹென்டர்சன் , யேல் பல்கலைக்கழகம் , சப்போரோ மருத்துவ பல்கலைக்கழகம் , மருத்துவ நரம்பியல் ,

Yale scientists repair injured spinal cord using patients' own stem cells

Intravenous injection of bone marrow derived stem cells (MSCs) in patients with spinal cord injuries led to significant improvement in motor functions, researchers from Yale University and Japan report Feb. 18 in the ....

Stepheng Waxman , Masanori Sasaki , Osamu Honmou , Jefferyd Kocsis , Yale University , Sapporo Medical University , Clinical Neurology , Medicine Health , Critical Care Emergency Medicine , Death Dying , யேல் பல்கலைக்கழகம் , சப்போரோ மருத்துவ பல்கலைக்கழகம் , மருத்துவ நரம்பியல் , மருந்து ஆரோக்கியம் , முக்கியமான பராமரிப்பு அவசரம் மருந்து , இறப்பு இறக்கும் ,