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Federal committee recommends more research, care for patients with sickle cell Sickle cell patients may experience frequent infections, fatigue, pain, eye problems and a higher risk of stroke. (Source: Cronkite News) By Harry Croton | January 28, 2021 at 7:58 AM MST - Updated January 29 at 1:28 PM PHOENIX â Health care experts are calling on federal and state agencies to take action to provide better care for the estimated 100,000 Americans who suffer from sickle cell disease. Sickle cell is the most common inherited blood disorder in the U.S. and disproportionately affects African Americans, occurring in 1 out of every 365 births of Black children, according to the U.S. Centers for Disease Control and Prevention. Sickle cell patients may experience frequent infections, fatigue, pain, eye problems and a higher risk of stroke. ....