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Novel hybrid device to boost research on metastatic process of breast cancer cells European researchers are working on a novel hybrid device to better understand the metastatic process of cancer cells traveling from breast to bone and fast screen new drugs against it. The spread of cancer cells to other parts of the body, known as metastasis, is the main cause of cancer-related deaths. According to the US National Cancer Institute, in 2018 there were 9.5 million deaths caused by cancer worldwide, and a high percentage of those involved tumors that had spread across the body. However the metastatic process remains one of the most enigmatic aspects of the disease. To understand it, we have to take a step back and look at the biology of the primary tumor. ....
Treating severe COVID-19 patients with the anticancer drug bevacizumab may reduce mortality and speed up recovery, according to a small clinical study in Italy and China that was led by researchers at Karolinska Institutet in Sweden between February and April 2020. ....
Intensive BP lowering reduces cardiovascular risk in patients exposed to air pollution Evidence suggests particulate matter is the air pollutant which poses the greatest threat to global health. Studies have shown that exposure to particulate matter smaller than 2.5 microns is associated with acute and chronic elevations in blood pressure (BP) as well as hypertension. In the study The Benefits of Intensive Versus Standard Blood Pressure Treatment According to Fine Particulate Matter Air Pollution Exposure published this week in the journal Hypertension, researchers at University Hospitals (UH) and Case Western Reserve University (CWRU) School of Medicine found intensive BP lowering is effective in reducing cardiovascular risk in patients exposed to high levels of air pollution. ....
Elevated ACE2 and inflammation levels increase risk for pregnant women infected with SARS-CoV-2 Among the hundred million or so cases of coronavirus disease 2019 (COVID-19) that have occurred since the pandemic began, pregnant women have been a conspicuous risk group. However, the exact nature of the risk they and their fetuses face, and the mechanism by which it operates, is far from clear. A new preprint research paper posted to the medRxiv server throws some light on this area by revealing the presence of significant inflammation at the maternal-fetal interface. Study: SARS-CoV-2 infection in pregnancy is associated with robust inflammatory response at the maternal-fetal interface. Image Credit: Natalia Grevtsova / Shutterstock ....
Obesity may contribute toward neural tissue vulnerability, exacerbate Alzheimer s disease New research from the University of Sheffield has found being overweight is an additional burden on brain health and it may exacerbate Alzheimer s disease. The pioneering multimodal neuroimaging study revealed obesity may contribute toward neural tissue vulnerability, whilst maintaining a healthy weight in mild Alzheimer s disease dementia could help to preserve brain structure. The findings, published in The Journal of Alzheimer s Disease Reports, also highlight the impact being overweight in mid-life could have on brain health in older age. More than 50 million people are thought to be living with Alzheimer s disease and despite decades of ground breaking studies and a huge global research effort we still don t have a cure for this cruel disease. ....