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Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China The pathogenesis of Alzheimer s disease is complex, and early-onset Alzheimer s disease (EOAD) is mostly influenced by genetic factors. Presenilin-1, presenilin-2 (PSEN2), and amyloid precursor protein are currently known as the three main causative genes for autosomal dominant EOAD, with the PSEN2 mutation being the rarest. In this study, we reported a 56-year-old Chinese Han proband who presented with prominent progressive amnesia, aphasia, executive function impairment, and depression 5 years ago. The 3-year follow-up showed that the patient experienced progressive brain atrophy displayed on magnetic resonance imaging (MRI) and dramatic cognitive decline assessed by neuropsychological evaluation. This patient was clinically diagnosed as EOAD based on established criteria. A heterozygous variant (NM 000447.2: c.1106T>C) of PSEN2 was identified for the first time in this patient a ....
email article A physical rehabilitation program tailored to people diagnosed with acute decompensated heart failure appeared to improve physical functioning, quality of life, and even depression, researchers reported. After 3 months, patients who were classified as frail or pre-frail improved by an average 1.5 units in the Short Physical Performance Battery compared with patients who were not involved in the program (95% CI 0.9-2.0, P ....
KEY POINTS Virtual care has the potential to improve access to health care for people with Alzheimer disease and related dementias, especially in the context of the coronavirus disease 19 (COVID-19) pandemic. Videoteleconferencing is a well-studied means of virtual care that has successfully been used to remotely assess, diagnose and manage such patients. Successful telemedicine programs often have access to supplemental clinical information to aid in diagnosis and involve interdisciplinary teams to manage patient complexity. Evidence regarding direct-to-home virtual care for people with Alzheimer disease and related dementias is lacking; this model is associated with unique challenges that must be considered as virtual care becomes a more common approach to health care delivery. ....
Background: Major depressive disorder (MDD) presents with emotional and somatic symptoms and sometimes subjective cognitive complaints (SCCs). This study developed a collaborative method to integrate SCC assessment for evaluating late-life MDD. Methods: Residents aged > 50 years in the Community Medicine Research Center of Keelung Chang Gung Memorial Hospital in Taiwan during 2017– 2018 were prospectively recruited in this study. The participants were asked to report their depressive tendency and SCCs using the Taiwanese Depression Questionnaire (TDQ) and the AD8, respectively, and were administered psychiatric evaluation through the Mini–International Neuropsychiatric Interview (MINI). The participants were divided into elderly (age≥ 65 years) and older adult (age 50– 65) groups. The MDD predictive powers were assessed using logistic regression and receiver operating characteristic (ROC) curve analyses. ....