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Immunotherapy alone extended life for metastatic lung cancer patients with KRAS mutation


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IMAGE: Charu Aggarwal, MD, MPH (top), Ronac Mamtani, MD, (bottom left), and Lova Sun, MD.
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Credit: Penn Medicine
PHILADELPHIA Real-word evidence is suggesting, for the first time, the most beneficial treatment courses that could help extend the lives of patients with metastatic non-small cell lung cancer, according to research from the
Abramson Cancer Center at the University of Pennsylvania.
In a new study published online today in
JAMA Oncology, researchers show that patients harboring a KRAS gene mutation with high levels of PDL-1 lived longer when treated with immunotherapy alone, compared to patients without this mutation. This survival difference by KRAS status was not seen, however, in patients treated with both chemotherapy and immunotherapy, suggesting combination therapy for patients without the mutation may be preferred. ....

University Of Pennsylvania , United States , Charu Aggarwal , Lova Sun , Rogerb Cohen , Coreyj Langer , Ronac Mamtani , Perelman School Of Medicine , Abramson Cancer Center , Flatiron Health , Perelman School , Associate Professor , Lung Cancer Excellence , Miles Tan , Medicine Health , Clinical Trials , பல்கலைக்கழகம் ஆஃப் பென்சில்வேனியா , ஒன்றுபட்டது மாநிலங்களில் , லோவா சூரியன் , பெரல்மேன் பள்ளி ஆஃப் மருந்து , பிளாட்டிரான் ஆரோக்கியம் , பெரல்மேன் பள்ளி , இணை ப்ரொஃபெஸர் , நுரையீரல் புற்றுநோய் சிறப்பானது , மருந்து ஆரோக்கியம் ,

Patients in cancer remission at high risk for severe COVID-19 illness


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PHILADELPHIA Patients with inactive cancer and not currently undergoing treatments also face a significantly higher risk of severe illness from COVID-19, a new study from
Penn Medicine published online today in
JNCI Cancer Spectrum shows. Past reports have established an increased risk of severe disease and death for sick or hospitalized cancer patients with COVID-19 compared to patients without cancer, but less is known about patients in the general population.
The findings underscore the importance of COVID-19 mitigation, like social distancing and mask wearing, and vaccinations for all patients, not just those recently diagnosed or with active disease.
Patients who have cancer need to be careful not to become exposed during this time, said senior author ....

University Of Pennsylvania , United States , Anhn Le , Roberth Vonderheide , Lova Sun , Abigail Doucette , Ivan Maillard , Ronac Mamtani , Marylyn Ritchie , Erin Bange , Alexander Huang , Daniel Rader , Sanjna Surya , Peter Gabriel , Anurag Verma , Angela Demichele , Karan Maxwell , Sheena Desai , Basser Center , Perelman School Of Medicine , Abramson Cancer Center , Penn Medicine , Perelman School , Penn Medicine Biobank , Medicine Health , Infectious Emerging Diseases ,