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E-Mail IMAGE: A researcher at Calibr, the drug discovery division of Scripps Research, working in the high-throughput screening facility used to identify potential COVID-19 therapies. view more Credit: Scripps Research June 3, 2021 - LA JOLLA, CA Mining the world s most comprehensive drug repurposing collection for COVID-19 therapies, scientists have identified 90 existing drugs or drug candidates with antiviral activity against the coronavirus that s driving the ongoing global pandemic. Among those compounds, the Scripps Research study identified four clinically approved drugs and nine compounds in other stages of development with strong potential to be repurposed as oral drugs for COVID-19, according to results published June 3 in the journal ....
E-Mail IMAGE: Sumit Chanda, co-senior study author and director of the Immunity and Pathogenesis Program at Sanford Burnham Prebys. view more Credit: Sanford Burnham Prebys Medical Discovery Institute LA JOLLA, CALIF. - March 16, 2021 - A Nature study authored by scientists at Sanford Burnham Prebys Medical Discovery Institute and the University of Hong Kong shows that the leprosy drug clofazimine, which is FDA approved and on the World Health Organization s List of Essential Medicines, exhibits potent antiviral activities against SARS-CoV-2 and prevents the exaggerated inflammatory response associated with severe COVID-19. Based on these findings, a Phase 2 study evaluating clofazimine as an at-home treatment for COVID-19 could begin immediately. ....
Print Scientists at the Sanford Burnham Prebys Medical Discovery Institute in La Jolla say they have identified the sensor in human lungs that detects SARS-CoV-2, the virus that causes COVID-19, and signals the body to mount an antiviral response. The discovery may lead to improved treatment for those diagnosed with the disease. The sensor in the lungs, called MDA-5, was found to be “the immune cop that’s tasked to keep an eye out for SARS-CoV-2 and call for backup,” said Sumit Chanda, director of the immunity and pathogenesis program at SBP and senior author of the study. “MDA-5 recognizes replicating viruses in lung cells and activates interferon,” Chanda said. Interferon, a signaling protein released by cells in the immune system, is “the body’s own frontline defender against viral invasion,” he said. ....
The virus SARS-CoV-2, which causes COVID-19. Sanford Burnham Prebys Medical Discovery Institute Senior study author Sumit Chanda, Ph.D., director of the Immunity and Pathogenesis Program at Sanford Burnham Prebys. Previous Next Newswise LA JOLLA, CALIF. – Jan 12, 2020 – Scientists at Sanford Burnham Prebys Medical Discovery Institute have identified the sensor in human lungs that detects SARS-CoV-2 and signals that it’s time to mount an antiviral response. The study, published today in Cell Reports, provides insights into the molecular basis of severe disease and may enable new strategies for the treatment and prevention of COVID-19. “Our research has shown that MDA-5 is the immune cop that’s tasked to keep an eye out for SARS-CoV-2 and call for back-up,” says Sumit Chanda, Ph.D., director of the Immunity and Pathogenesis Program at Sanford Burnham Prebys and senior author of the study. “MDA-5 recognizes replicating viruses in ....
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